Top Close glossary Censoring A common phenomenon in all studies involving duration data and terminating events - requiring processing before the analysis can proceed.
Open in a separate window Example of interpreting IRR. No statistically significant association was observed for number of pregnancies IRR between 0. Natural menopause showed no association with t 14;18 frequency. For the subgroup of women who had used both IRR were increased 2.
Discussion The biologic mechanisms for developing NHL are currently unclear. Prevalence and frequency of t 14;18 -positive cells in healthy individuals are associated with known FL risk factors like increasing age and male sex [ 27283241 ].
Epidemiologic observations link reproductive factors and gender-specific hormone use with risk of NHL [ 1933 ]. To the best of our knowledge, this is the first study investigating a possible association between circulating t 14;18 -positive cells and reproductive factors and exogenous hormone use in healthy females.
In bivariate analyses, we found some positive associations between the t 14;18 prevalence and MHT use ever vs. In the multivariable model, only age remains a statistically significant predictor showing a positive association with the t 14;18 prevalence.
Restricting the multivariable model to postmenopausal women did not change the risk estimates significantly data not shown.
Restricting the multivariable model to postmenopausal women yielded comparable risk estimates data not shown. The separate parameter estimate for MHT was not statistically significant. Based on these results, it could be speculated that exposure at younger ages may have a positive impact on t 14;18while it does not affect prevalence.
Our multivariable analyses revealed no statistically significant parameter estimates for number of pregnancies, neither on prevalence nor on frequency.
However, we observed decreased risks on t 14;18 frequency for women with at least one pregnancy. In line with this, two other studies showed an enhanced risk of NHL for null and low parity [ 4344 ].
Our results of the positive association between ever use of OC and t 14;18 frequency are consistent with Costas et al. This variation, however, might at least partly be attributable to low sample sizes.
Type of menopause was investigated by Morton et al. Inconclusive findings were published for MHT use. Among postmenopausal women, Mildon et al.
Similar results were presented in a pooled analysis of the InterLymph case—control study for ever versus never MHT users with an OR of 0. These results are in line with our bivariate age-adjusted findings restricted to postmenopausal women.
Based on the 7-day medication, we identified The prevalence among women currently not taking any menopausal therapy is slightly lower We cannot completely exclude a possible bias due to a changing pattern of MHT use over time e.
Heterogeneous results in published risk estimates concerning NHL and hormone-associated factors in women might be attributable to a lack of differentiation of the NHL subtypes in many analyses.
Only very few studies assessed possible risk factors separately for specific NHL subtypes. Other influencing factors include study setting, selection of confounding factors, small sample sizes, limited age range of participants, formulation of exogenous hormones, and duration of the application.
We observed a curvilinear association of age with both translocation prevalence and frequency. This observation is consistent with the age-specific incidence of FL. It is, however, unclear, why in older ages t 14;18 prevalence and frequency decline, while lymphoma incidence continues to increase.
Our analysis is based on the baseline examination of a population-based cohort, which is characterized by a high life-time prevalence of OC and MHT use [ 50 ]. The population-based sampling together with a high response proportion compared to other German cohorts [ 51 ] limit major selection bias and increases the external validity of these results.Analysis of data from the National Survey of Family Growth indicates that use of emergency contraception in the United States has increased after changes in its prescription status in The variables for this analysis included age, poverty status, race or ethnicity, and the interaction between poverty status and race or ethnicity, in addition to the main effects of method and duration and the interaction effect between them.
Finally, we estimated a model to explore effects of religion on contraceptive effectiveness. The combined oral contraceptive pill (COCP), often referred to as the birth-control pill or simply "the pill", is a birth control method that includes a combination of an estrogen and a progestin (progestogen).
When taken by mouth every day, these pills inhibit female fertility.B.C. type: Hormonal. Development of Economic Analysis Sixth Edition Development of Economic Analysis has been instrumental in introducing a generation of students to the history of economic thought.
Emergency Contraception Demonstration Project. As early as , researchers and clinicians recognized that a high dose of combination estrogen/progestin oral contraceptives could prevent pregnancy if taken shortly after an unprotected act of . HS-Ch. STUDY. PLAY. contraception.
a type of oral contraceptive that contains one level of hormones in all the active pills. biphasic pill. a type of birth control pill that contains only synthetic progesterone and no estrogen.
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subdermal contraceptive implant.